After being rescued from the '90s, Francois joined the side of the angels partially out of obligation towards the powers that be for sparing his life, partially because it is all he knows how to do. He participated in the race to stop Kazimir's nuclear legacy from destroying the world, almost at the cost of his own life. For a time, he possessed Kazimir's power as his own until it was burned out of him by its healing counterpart, his old power, and now, is more or less an ordinary man if you don't count how long he's been on this earth.
Throughout the game, he spent his time helping various factions with common interests, both the Ferrymen and Endgame, as either a medic or another set of hands holding a gun. He fell in love with Teodoro Laudani and married him. He was granted, through super ability means, the 2011-relevant education of a surgeon. He was leading something of a strange double-life, in which he knew nothing could settle until certain battles were won, but determined to carry out a normal life at the same time, with a house, career, and husband.
Then everything got worse.
War was declared within the United States of America. As he did back in the 1940s, Francois sought a means to fight back on behalf of his Evolved friends and on behalf of the atrocities he witnessed himself, and fell in with Wolfhound, offering up his services as both an experienced soldier, investigator and hunter of bad guys, and medic. Having glimpsed a future where he slips somewhere darker than he thinks he is cut out for, the discipline of a tactical group appealed to his sanity.
By the time the war was over, and everyone was picking up the pieces of their lives, Teo decided he needed to leave for an undisclosed measure of time. Upon realising he did not intend to bring Francois with them, they parted ways after a heated argument.
Francois sought permission to pursue a lead on behalf of Wolfhound that took him overseas, deciding to return a little to form in his solo pursuit of a villain halfway across the world. He didn't disappear, exactly, as Hana's technopathic capabilities made it simple to keep in private contact, but there were long stretches of time in which he kept to himself. Some of this was checking on anything Vanguard-related that may linger as well as pursuing his mark. Finally, sometime in mid-2015, he returned with one of the thirty-six conspirators who would be sentenced to death a year later, buying his way back into the States for virtue of having ferreted his quarry out of the Netherlands.
This may or may not have contributed to Wolfhound's reputation, but what it did for Francois was teach him his old tactics in a new world, engaging in light espionage and a talent for improvisation that makes him a good agent to deploy on his own, but he likewise continued to train up his combat skills so as to operate within a team as well. Wolfhound became lawfully incorporated and he along with it.
His personal life has kindly sadly whittled down with his friends either overseas, missing, dead, or simply moved on, and he feels a little like he's entered yet another future age in which he doesn't temporally belong, but no matter. He's thinking about writing a book, and otherwise tries to stay capable and available for missions that come through Wolfhound.